Tigecycline was the first available drug in the new class of antibiotics called glycylcyclines. It is marketed by Wyeth with the brand name Tygacil. It was given FDA fast-track approval on June 17, 2005. It is only available in IV form.
Tigecycline targets both Gram-positive and Gram-negative bacteria including several multi-drug resistant pathogens, as well as anaerobes –and includes activity against methicillin-resistant Staphylococcus aureus (MRSA), Haemophilus influenzae, Neisseria gonorrhoeae, Stenotrophomonas maltophilia and multi-drug resistant strains of Acinetobacter baumannii. It has no activity against Proteus or Pseudomonas.
Common Brand Names of Tigecycline
Tygacil, the initial patent expires in 2016
Method of Activity
Side Effects of Linezolid
The most common side-effects of tigecycline are nausea, diarrhea and vomiting, usually occurring during the first two days of treatment. Other side effects include increased or decreased heart rate and infections. As is usual with other antibiotics, other organisms not susceptible to tigecycline can flourish.
2014, available from several online Canadian pharmacies, 70 to US$100 per 50mg vial.
http://en.wikipedia.org/wiki/Tigecycline accessed 21 Dec 2014
http://www.drugs.com/availability/generic-tygacil.html accessed 22 Dec 014