Trimethoprim for Chronic Prostatitis and PID - 4.0 out of 5 based on 4 votes
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Trimethoprim is a bacteriostatic antibiotic used to treat urinary tract infections causing Chronic Prostatitis, if sensitivity can be established by culture..

Trimethoprim is grouped by class to dihydrofolate reductase inhibitors and has been marketed under trade names including Monotrim, Proloprim and Triprim.

Trimethoprim and sulfamethoxazole were often used as combination therapy and known as co-trimoxazole, however the lowered effectiveness of this has meant that its use has declined markedly since the late 90's.

Susceptibility of Common Prostatitis-causing Pathogens:


Name of OrganismSusceptibility to Trimethoprim?
Aerobic bacteria
Acinetobacter sp.No
Aeromonas sp.Yes
Campylobacter coliNo
Corynebacterium jeikeiumNo
Enterobacter sp.Yes
Enterococcus sp.No
Escherichia coli sp.Yes
Haemophilus influenzaeYes
Klebsiella sp.Yes
Moraxella catarrhalisNo
Proteus mirabilisYes
Proteus vulgarisYes
Pseudomonas aeruginosaNo
Staphylococcus aureusYes
Staphylococcus saprophyticusYes
Streptococcus - A,B,C,GYes
Streptococcus viridansNo

.sp = Species

co-trimoxazole usesCo-Trimoxazole

Possible side-effects of Trimethoprim

Trimethoprim may cause side effects. Tell your doctor if any of these symptoms are severe or do not lessen:
  • upset stomach
  • diarrhea
  • vomiting
Call your Doctor immediately if you experience any of the following symptoms:
  • rash (hives)
  • itching
  • bluish-colored fingernails, skin or lips
  • difficulty breathing or swallowing
  • sore throat
  • fever or chills
  • joint aches
  • mouth sores
  • yellowing of the skin or eyes
  • unusual bruising or bleeding
  • paleness

 Warnings:

Use of trimethoprim for extended periods of time and/or at high doses may cause bone marrow depression. Signs such as sore throat, purpura or fever may be early indications of serious blood disorders. In such cases, complete blood counts should be done and the drug discontinued if abnormal blood counts are found.

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References:

http://cid.oxfordjournals.org/content/50/12/1641.full  accessed 25/12/2014
http://www.patient.co.uk/medicine/trimethoprim-for-infections  accessed 26/12/2014
http://www.drugs.com/cdi/trimethoprim.html  accessed 26/12/2014
http://www.rxlist.com/trimethoprim-drug.htm  accessed 26/12/2014

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